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Paricel (Rabeprazole Sodium)
Proton Pump Inhibitor for Effective Acid Suppression
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✅ Description:
Paricel is indicated in the management and treatment of the following conditions:
- Active duodenal and benign gastric ulcers
- Erosive or ulcerative GERD (Gastroesophageal Reflux Disease)
- Long-term maintenance therapy for GERD
- Symptomatic relief in moderate to severe GERD
- Zollinger-Ellison Syndrome
- Helicobacter pylori eradication, when used in combination with appropriate antibiotics, in peptic ulcer disease
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Pharmacological Action:
Rabeprazole is a proton pump inhibitor (PPI) that works by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme system on gastric parietal cells, significantly reducing gastric acid secretion at the source.
✔️ Recommended Dosage:
Peptic Ulcers:
- Duodenal Ulcer & Benign Gastric Ulcer: 20 mg once daily (morning).
- Duodenal ulcers typically heal within 4 weeks; gastric ulcers may take up to 6 weeks.
GERD:
- Erosive/Ulcerative GERD: 20 mg once daily for 4–8 weeks
- GERD Maintenance Therapy: 10–20 mg once daily, based on individual response
- Symptomatic GERD (without esophagitis): 10 mg once daily; if symptoms persist beyond 4 weeks, further evaluation is advised
Pediatric GERD (1–11 years):
- <15 kg: 5 mg daily, may increase to 10 mg
- ≥15 kg: 10 mg once daily for 12 weeks
Zollinger-Ellison Syndrome:
- Start with 60 mg once daily; may be titrated up to 120 mg/day depending on the patient's needs (given in divided doses if required)
H. pylori Eradication (7-day course):
- Rabeprazole 20 mg twice daily, with:
- Clarithromycin 500 mg twice daily
- Amoxicillin 1 g twice daily
- Take once daily doses in the morning before food to ensure compliance
- Tablets must be swallowed whole—do not chew or crush
✔️ Possible Side Effects:
Generally well tolerated. Occasionally may cause:
- Headache, dizziness, drowsiness
- Diarrhea, constipation, nausea, abdominal pain
- Vomiting, dry mouth, altered appetite
- Muscular pain
✔️ Drug Interactions:
- May reduce the absorption of ketoconazole, itraconazole, and atazanavir due to increased gastric pH
- No interaction with liquid antacids noted
- Avoid combining with atazanavir due to pH-dependent absorption issues
✔️ Contraindications:
- Hypersensitivity to rabeprazole or any tablet component
- Use is not advised during pregnancy or breastfeeding
✔️ Precautions & Warnings:
- Exclude malignancy prior to treatment initiation
- Long-term use (>1 year) may increase fracture risk (hip, wrist, spine)
- Risk of hypomagnesaemia and associated symptoms (tetany, arrhythmias, seizures)
- May reduce vitamin B12 absorption over prolonged use
- Potential association with SCLE (subacute cutaneous lupus erythematosus)
- Increased risk of GI infections (e.g., C. difficile, Salmonella, Campylobacter)
- Discontinue 5 days prior to Chromogranin A testing for accurate results
- Use caution in severe hepatic impairment
✔️ Use in Special Populations:
- Renal or mild-to-moderate hepatic impairment: No dosage adjustment required
- Pediatrics: Not recommended for children under 1 year or without clinical safety data
✔️ Overdose Management:
- Doses up to 160 mg/day have been reported without serious outcomes
- Supportive and symptomatic treatment is advised
- Rabeprazole is not dialyzable due to high plasma protein bindin
✔️ Storage Conditions:
- Store below 30°C, protect from light and moisture
- Keep out of reach of children
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
